Belladonna is the big bad of All Dogs Go to Heaven: The Series and the main adversary of An All Dogs Christmas Carol. She is a lavender whippet demon and the diabolical cousin of Annabelle. According to one of the angel puppies, she is known as the "Boogeydog". Belladonna is a symbol of Satan, as in the episode "La Doggie Vita", she tempts Charlie into working with her, Carface, and Killer, at a meat plant, and when she is shown to be Carface's mistress in An All Dogs Christmas Carol.

Like her cousin, Belladonna is voiced by Bebe Neuwith.